Endocrine Abstracts

ObjectivesThere is a paucity of real-world studies analyzing comorbidities, lab testing and treatment patterns of patients with chronic hypoparathyroidism (cHP). This study describes a large cohort of cHP patients identified using a diagnosis-based approach from a US claims database.MethodsThis retrospective study was conducted using a large (130 million individuals) claims database (HealthVerity Closed Payer...

ObjectivesThere is a paucity of real-world studies on the clinical burden and practice patterns associated with chronic hypoparathyroidism (cHP). This study assesses the comorbidities, treatment and lab testing patterns in cHP patients identified using surgery-based criteria.MethodsThis was a retrospective study conducted using a large (130 million individuals) US claims database (HealthVerity Closed Payer Cl...

Objectives: Antagonism of the IGF-1 receptor (IGF-1R) has been shown to reduce TED-related inflammation and proptosis. VRDN-001, a high-affinity antagonist antibody to IGF-1R, has distinct pharmacological properties that may enable differentiated dosing and better efficacy than observed with other antibodies. We assessed VRDN-001 in vitro pharmacology compared with teprotumumab and clinical proof of concept in a phase 1/2 randomized controlled trial (NCT05176639)....

MicroRNAs (miRNA) are small (18–24 nts) non-coding RNAs which are part of an evolutionarily highly conserved intracellular mechanism to regulate gene expression in a sequence-specific manner. These regulatory RNAs function by acting as sequence-specific guides which recruit multi-protein complexes to target mRNA sequences which are subsequently silenced. miRNAs are processed from primary transcripts (pri-miRNA) by cellular components which are also at least partially invo...

Michael Besser, St Bartholomew's and Royal London School of Medicine and Dentistry, London, UK AbstractProfessor Michael Besser qualified in medicine in 1960 at the Medical School of St Bartholomew's Hospital, and then undertook a number of junior medical posts there and at the Royal Postgraduate Medical School and the Royal Brompton Hospital. He started his academic work initially as junior lecturer in therapeutics i...

Adrian Clark, Barts & the London, QMUL, London, United Kingdom. AbstractAdrian Clark graduated in Medicine from St Bartholomew’s Hospital Medical College in 1976. After several junior medical training posts at Barts, Nottingham, Hammersmith and Guys, he spent two years at the NCI in Bethesda working on the cloning of the EGF receptor with Ira Pastan, then later moved to work for three years with Kevin Catt, al...

Polycystic Ovary Syndrome (PCOS), the most common endocrinopathy affecting reproductive-aged women, is characterized by oligo-/anovulation, hyperandrogenism and polycystic ovaries. In PCOS women with anovulatory infertility, the accepted first-line treatment is clomiphene citrate (CC). For patients resistant to CC, laparoscopic ovarian drilling (LOD) is recommended as a second-line therapy. Whilst very effective, LOD is an invasive technique requiring general anaesthesia and a...

Objective: Arthropathy is the commonest morbidity in acromegaly and the main determinant of quality of life in these patients. Most of current knowledge is derived from studies using conventional x-rays. This study aims to characterise acromegalic arthropathy using modern imaging techniques.Methods: Case control study comprising of 60 acromegaly patients (29 males, mean age 54.8± 12.9yrs) and 300 age/gender-matched controls from the publicly availab...

Introduction: The androgen receptor (AR) mediates the peripheral effects of testosterone. The main mechanism of action for the AR is direct regulation of gene transcription. Available evidence suggests that the number of CAG repeats in exon-1 of the AR gene is negatively correlated with transcriptional activity of the AR and that CAG repeat number links to mortality rate in T2DM men. The aim of this analysis was to determine the association between CAG repeat number and all ca...

We describe a 68 year lady who was found to have bilateral adrenal masses (7 cm on the right side and 1.3 cm on the left) during investigations for gastrointestinal symptoms, in early 2016. Biochemistry revealed high urinary normetanephrines of 41.7pmol/24h (ref 0–3) and metanephrines of 40pmol/24h (ref 0–1.8). A PET and MIBG scan revealed uptake in both adrenals and therefore a diagnosis of bilateral phaeochromocytoma was made. The patient had complained of occasion...